Small heat-shock proteins and their role in mechanical stress
نویسندگان
چکیده
منابع مشابه
Heat shock proteins and their role in human diseases
Elevated expression of heat shock proteins (HSPs) has been demonstrated following various forms of stress, such as heat, heavy metal or ethanol treatment, hypoxia, ischemia, and they are also upregulated in several diseases and infections, as their most important function is to protect cells from the harmful effects of stress. As molecular chaperones they regulate the biosynthesis, folding/unfo...
متن کاملA first line of stress defense: small heat shock proteins and their function in protein homeostasis.
Small heat shock proteins (sHsps) are virtually ubiquitous molecular chaperones that can prevent the irreversible aggregation of denaturing proteins. sHsps complex with a variety of non-native proteins in an ATP-independent manner and, in the context of the stress response, form a first line of defense against protein aggregation in order to maintain protein homeostasis. In vertebrates, they ac...
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Epigenetic alterations, including DNA acetylation, hypermethylation and hypomethylation, and the associated transcriptional changes of the affected genes are central to the evolution and progression of various human cancers, including pancreatic cancer. Cancer-associated epigenetic alterations are attractive therapeutic targets because such epigenetic alterations, unlike genetic changes, are po...
متن کاملThe small heat shock proteins and their role in human disease.
Small heat shock proteins (sHSPs) function as molecular chaperones, preventing stress induced aggregation of partially denatured proteins and promoting their return to native conformations when favorable conditions pertain. Sequence similarity between sHSPs resides predominately in an internal stretch of residues termed the alpha-crystallin domain, a region usually flanked by two extensions. Th...
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ژورنال
عنوان ژورنال: Cell Stress and Chaperones
سال: 2020
ISSN: 1355-8145,1466-1268
DOI: 10.1007/s12192-020-01095-z